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Objective . To assess the effect of different lasers on cyclophosphamide- (CTX-) induced leucopenia in rats.  Methods . 11 rats were normal control and 55 rats were injected with a dose of 80 mg/kg CTX for the first time and 40 mg/kg on the 6th and the 11th days to establish a leucopenia model. Rats of the irradiation groups received a 5-minute laser irradiation with either single 10.6   μ  m or 650 nm laser or alternatively 10.6   μ  m–650 nm laser irradiation, besides a sham treatment on acupoint Dazhui (DU 14) and acupoint Zusanli (ST 36) of both sides, 8 times for 16 days. Normal and model control group received no treatment.  Results . On day 16 after the first CTX injection, the WBC counts from all the laser irradiation groups were significantly higher than those from the model control and the sham group ( P  < 0.05), while there were no significant differences compared with the normal control ( P  > 0.05). The TI of 10.6   μ  m–650 nm laser irradiation group was significantly higher than that of the model control group ( P  < 0.05).  Conclusions . The single and combined 10.6   μ  m and 650 nm laser irradiation on ST36 and DU14 accelerated the recovery of the WBC count in the rats with leucopenia.

The Effect of Different Laser Irradiation on Cyclophosphamide-Induced Leucopenia in Rats