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Objective.  To evaluate the effect of petroleum ether extracts of  Curcuma zedoaria  on the proliferation of human triple negative breast cancer cell line MDA-MB-231.  Methods.  The reagents were isolated from  Curcuma zedoaria  by petroleum ether fraction. It was assayed by CCK8 for MDA-MB-231 cellular viability with various concentrations and days, cell cycle analyses, Western Blot analysis, and Realtime Reverse Transcriptase PCR analyses for chemokines molecules including E-cadherin, and E-selectin, and adhesion molecules including CCR7, SLC, SDF-1, and CXCR4. Epirubicin was used as control in the study.  Results.  MDA-MB-231 cells were inhibited by petroleum ether extracts of  Curcuma zedoaria  ( P  < 0.05), and the inhibition rate was dependent on concentrations and time. Petroleum ether extracts of  Curcuma zedoaria  as well as Epirubicin produce a significant G0/G1 cell cycle arrest. The level of expression of proteins E-cadherin and E-cadherin mRNA was significantly increased, while proteins SDF-1, CCR7, and CXCR4 mRNA were decreased after being incubated with petroleum ether extracts of  Curcuma zedoaria  at the concentrations of 300   μ  g/mL than control ( P  < 0.05). The differences were that the protein CXCR4 mRNA expression level was higher than vehicle.  Conclusions.  MDA-MB-231 cells were inhibited by petroleum ether extracts of  Curcuma zedoaria .

Extracts fromCurcuma zedoariaInhibit Proliferation of Human Breast Cancer Cell MDA-MB-231In Vitro