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A personalized probiotic microfluidic chip system has been established and used to screen the probiotics which had the highest value of IFN- γ /IL-10 or IL-10/IFN- γ  among six probiotics, including  L. paracasei  BRAP01,  L. acidophilus  AD300,  B. longum  BA100,  E. faecium  BR0085,  L. rhamnosus  AD500, and  L. reuteri  BR101. One hundred volunteers were included and their PBMCs were collected and stimulated by the six probiotics. People who belonged to the IFN- γ  group took the probiotics that exerted the highest ratio of IFN- γ /IL-10 and vice versa in IL-10 group. A significant increase in NK cytotoxicity of 69 volunteers in the IFN- γ  group was observed compared to the IL-10 group ( n  = 21) and control group ( n  = 10). The result also showed that  L. paracasei  BRAP01 and  L. acidophilus  AD300 were the two dominant inducers in IFN- γ  group which yielded higher value of IFN- γ /IL-10 than the other 4 probiotics, while  L. reuteri  BR101 was the most effective agent on the ratio of IL-10/IFN- γ  in the IL-10 group. Our finding highlighted the concept of personalized probiotics and also provided a good foundation to investigate the probiotics with NK activity.

journal of immunology research

Daily Intake of Probiotics with High IFN-<i>γ</i>/IL-10 Ratio Increases the Cytotoxicity of Human Natural Killer Cells: A Personalized Probiotic Approach

Daily Intake of Probiotics with High IFN-γ/IL-10 Ratio Increases the Cytotoxicity of Human Natural Killer Cells: A Personalized Probiotic Approach