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Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gave  N   ′ -[( Z )-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4 H -pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL 1 ), which was characterized by NMR spectroscopy and single-crystal X-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. The reaction of HL 1  with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies. The compounds were screened for their  in vitro  cytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. Results showed that the compounds are potent against HL-60 cells with the IC 50  value ≤5  μ M, while some of the compounds were active against few studied Gram-positive bacteria.

bioinorganic chemistry and applications/bioinorganic chemistry and applications

Synthesis, Characterization, and Biological Activity ofN′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes