English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background . Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk. The mechanisms remain uncertain.  Aim . We hypothesize that supraphysiological concentrations of 1,25 (OH) 2  vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and  DKK1 .  Subjects and Methods . We measured serum sclerostin and  DKK1  in 34 patients (21 F, 13 M) aged mean (SD) 61.3 (15.6) years with vitamin D deficiency/insufficiency treated with a loading dose of vitamin D 2  (300,000 IU) intramuscularly. Blood samples were taken at baseline and serially up to 3 months.  Results . Serum 1,25 (OH) 2  vitamin D increased markedly at 3 months (mean (SD) baseline 116 (63), 3 months : 229 (142) pmol/L,  P  < 0.001). There was a significant correlation between sclerostin and  DKK1  at baseline ( r  = 0.504,  P  = 0.002) and at 3 months ( r  = 0.42,  P  = 0.013). A significant inverse correlation was observed between sclerostin and eGFR at 3 months ( r  = −0.494,  P  = 0.007). Sclerostin increased significantly at 3 months ( P  = 0.033). In a multilinear regression analysis with % change in sclerostin and  DKK1  as dependent variable, a positive significant association was observed with % change in 1,25 (OH) 2  vitamin D ( P  = 0.038), independent of changes in PTH and following correction for confounders such as age, gender, BMI, BMD and eGFR.  Conclusions . Supraphysiological concentration in 1,25 (OH) 2  vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling. This may have detrimental effects on bone.

Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2(300,000 IU)

Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D₂(300,000 IU)