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The present study was designed to explore the effects of  GAS6  and  AXL  gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents'  GAS6  rs8191973,  GAS6  rs8191974,  AXL  rs4802113, and  AXL  rs2304232 polymorphisms. Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype of  GAS6  rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of  AXL  rs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of  AXL  rs4802113. Boys with both the GG genotype of  GAS6  rs8191973 and the GG genotype of  GAS6  rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of the  GAS6  rs8191973 and the A allele of the  GAS6  rs8191974. In conclusion,  GAS6  and  AXL  polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys.

Effect ofGAS6andAXLGene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents