English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Multidrug-resistant (MDR)  Acinetobacter baumannii  infections are difficult to treat owing to the extremely limited armamentarium. Expectations about antimicrobial peptides' use as new powerful antibacterial agents have been raised on the basis of their unique mechanism of action.  Musca domestica  cecropin (Mdc), a novel antimicrobial peptide from the larvae of Housefly ( Musca domestica ), has potently active against Gram-positive and Gram-negative bacteria standard strain. Here we evaluated the antibacterial activity of Mdc against clinical isolates of MDR- A. baumannii  and elucidate the related antibacterial mechanisms. The minimal inhibitory concentration (MIC) of Mdc was 4   μ  g/mL. Bactericidal kinetics of Mdc revealed rapid killing of  A. baumannii  (30 min). Flow cytometry using viability stain demonstrated that Mdc causes  A. baumannii  membrane permeabilization in a concentration- and time-dependent process, which correlates with the bactericidal action. Moreover, transmission electron microscopic (TEM) examination showed that Mdc is capable of disrupting the membrane of bacterial cells, resulting in efflux of essential cytoplasmic components. Overall, Mdc could be a promising antibacterial agent for MDR- A. baumannii  infections.

the scientific world journal/thescientificworldjournal

Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment of<i>Acinetobacter baumannii</i>Susceptible to<i>Musca domestica</i>cecropin

Transmission Electron Microscopic Morphological Study and Flow Cytometric Viability Assessment ofAcinetobacter baumanniiSusceptible toMusca domesticacecropin