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Background . Inflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis.  Aim . To determine differences in levels of proinflammatory and prothrombotic markers such as high sensitivity C-reactive protein (hs-CRP) and fibrinogen in subjects with normal glucose tolerance (NGT), prediabetes, and T2DM and to establish their relationship with other cardiovascular risk factors before clinical manifestations of cardiovascular disease.  Methods . We conducted a nonrandomized, cross-sectional assay in a hospital at México City. The levels of hs-CRP and fibrinogen were measured and compared according to glucose tolerance status.  Results . We enrolled 1047 individuals and they were distributed into NGT  n  = 473, pre-DM  n  = 250, and T2DM  n  = 216. There was a statistical difference between NGT and T2DM groups for fibrinogen ( P  = 0.01) and hs-CRP ( P  = 0.05). Fibrinogen and hs-CRP showed a significant positive correlation coefficient ( r  = 0.53,  P <0.0001). In a multiple stepwise regression analysis, the variability in fibrinogen levels was explained by age, HbA1c, and hs-CRP (adjusted  R   2  = 0.31,  P <0.0001), and for hs-CRP it was explained by BMI and fibrinogen (adjusted  R   2  = 0.33,  P <0.0001).  Conclusion . Inflammation and prothrombotic state are present in people with T2DM lacking cardiovascular disease. Fibrinogen and Hs-CRP are positively correlated. Fibrinogen and hs-CRP concentrations are predominantly determined by BMI rather than glucose levels.

Proinflammatory and Prothrombotic State in Subjects with Different Glucose Tolerance Status before Cardiovascular Disease