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Carassius auratus  complex formula, including  Carassius auratus , Rhizoma dioscoreae,  Lycium chinense , and  Rehmannia glutinosa  Libosch, is a combination prescription of traditional Chinese medicine, which has always been used to treat diabetes mellitus in ancient China. In this study, we provided experimental evidence for the use of  Carassius auratus  complex formula in the treatment of high fat diet combined streptozotocin- (STZ-) induced type 2 diabetes.  Carassius auratus  complex formula aqueous extract was prepared and the effects of it on blood glucose, serum insulin, adipose tissue weight, oral glucose tolerance test (OGTT), total cholesterol, and triglyceride (TG) levels in mice were measured. Moreover, adiponectin, TG synthesis related gene expressions, and the inhibitory effect of aldose reductase (AR) were performed to evaluate its antidiabetic effects. After the 8-week treatment, blood glucose, insulin levels, and adipose tissue weight were significantly decreased. OGTT and HOMA-IR index showed improved glucose tolerance. It could also lower plasma TG, TC, and liver TG levels. Furthermore,  Carassius auratus  complex formula could inhibit the activity of AR and restore adiponectin expression in serum. Based on these findings, it is suggested that  Carassius auratus  complex formula possesses potent anti-diabetic effects on high fat diet combined STZ-induced diabetic mice.

Antidiabetic Effects ofCarassius auratusComplex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice