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In infectious synovitis caused by  Mycoplasma synoviae  chicken chondrocytes (CCH) may come into direct contact with these bacteria that are also capable of invading CCH  in vitro . In this study, phenotype microarrays were used to evaluate the influence of  Mycoplasma synoviae  on the global metabolic activity of CCH. Therefore, CCH were cultured in the presence of 504 individual compounds, spotted in wells of 11 phenotype microarrays for eukaryotic cells, and exposed to  Mycoplasma synoviae  membranes or viable  Mycoplasma synoviae.  Metabolic activity and sensitivity of normal cells versus infected cells were evaluated. Metabolic profiles of CCH treated with viable  Mycoplasma synoviae  or its membranes were significantly different from those of CCH alone. CCH treated with  Mycoplasma synoviae  membranes were able to use 48 carbon/nitrogen sources not used by CCH alone. Treatment also influenced ion uptake in CCH and intensified the sensitivity to 13 hormones, 5 immune mediators, and 29 cytotoxic chemicals. CCH were even more sensitive to hormones/immune mediators when exposed to viable  Mycoplasma synoviae . Our results indicate that exposure to  Mycoplasma synoviae  or its membranes induces a wide range of metabolic and sensitivity modifications in CCH that can contribute to pathological processes in the development of infectious synovitis.

biomed research international

Phenotypic Characterization of<i>Mycoplasma synoviae</i>Induced Changes in the Metabolic and Sensitivity Profile of<i>In Vitro</i>Infected Chicken Chondrocytes

Phenotypic Characterization ofMycoplasma synoviaeInduced Changes in the Metabolic and Sensitivity Profile ofIn VitroInfected Chicken Chondrocytes