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Human   γδ   T cells display the principal characteristics of professional antigen-presenting cells (APCs), in addition to playing a vital role in immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether   γδ   T cells perform APC-like functions under pathological conditions. In this study, we showed that, in contrast to peripheral-derived   γδ   T cells directly isolated from PBMCs of gastric cancer patients, tumor-activated   γδ   T cells not only killed tumor cells efficiently but also strongly induced primary CD4 +  and CD8 +      αβ   T cells proliferation and differentiation. More importantly, they abrogated the immunosuppression induced by CD4 + CD25 +  Treg cells and induced the cytotoxic function of CD8 +      αβ   T cells from patients with gastric cancer. In conclusion, tumor-activated   γδ   T cells can induce adaptive immune responses through their APC-like functions, and these cells may be a potentially useful tool in the development of tumor vaccines and immunotherapy.

journal of immunology research

Tumor-Activated<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msup><mml:mrow><mml:mtext>T</mml:mtext><mml:mtext>C</mml:mtext><mml:mtext>R</mml:mtext><mml:mi mathvariant="bold">γ</mml:mi><mml:mi mathvariant="bold-italic">δ</mml:mi></mml:mrow><mml:mrow><mml:mtext>+</mml:mtext></mml:mrow></mml:msup></mml:mrow></mml:math>T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:…

Tumor-ActivatedTCRγδ+T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of