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Novel Schiff's bases  4a–e ,  5a ,  5b , and  6 , thiazolidine  7a–d , and pyrazolidine  8  have been synthesized using the versatile synthon 4-hydroxy-2,7-dimethyl-1,8-naphthyridine  1 . Reactions carried out under ultrasound irradiation showed higher rates and yields than those done under silent conditions. The newly synthesized compounds were evaluated for HepG2 cell growth inhibition. The results obtained revealed that the tested compounds possess inhibitory effect on the growth of HepG2 liver cancer cells. The results were compared to doxorubicin as a reference drug (IC 50 : 0.04). Compounds  4a  and  7b  showed the highest inhibition activity against the HepG2 cell line (IC 50 : 0.047 and 0.041 µM, resp.) among all the tested compounds.

the scientific world journal/thescientificworldjournal

An Efficient Sonochemical Synthesis of Novel Schiff’s Bases, Thiazolidine, and Pyrazolidine Incorporating 1,8-Naphthyridine Moiety and Their Cytotoxic Activity against HePG2 Cell Lines