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Nine alkaloids with three different structural skeletons were isolated from  Dicranostigma leptopodum  (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10- O -methylhernovine ( 1 ), nantenine ( 2 ), corytuberine ( 3 ), lagesianine A ( 4 ), and dihydrocryptopine ( 9 ) were first isolated from this plant. With a series of cytotoxic tests, compounds  2 ,  3 , and  7  displayed cytotoxicity against SMMC-7721 with IC 50  values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29   μ  M, respectively.

Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids fromDicranostigma leptopodum(Maxim.) Fedde