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Objectives . To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD).  Methods . Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF- α  receptor antagonist, for nine years.   Results . Treatment with infliximab resulted in major clinical and laboratory improvements without relevant side effects.   Conclusions . These results suggest that infliximab may be an effective treatment of severe CPDD.

Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up