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We evaluated the association between anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-mutated citrullinated vimentin antibodies (anti-MCV) with the presence of extra-articular (ExRA) manifestations in 225 patients with rheumatoid arthritis (RA). Ninety-five patients had ExRA and 130 had no ExRA. There was no association of anti-CCP and anti-MCV levels with the presence of ExRA as total group ( P  = 0.40 and  P  = 0.91, resp.). Making an analysis of individual manifestations, rheumatoid nodules were associated with positivity for rheumatoid factor (RF); ( P  = 0.01), anti-CCP ( P  = 0.048), and anti-MCV ( P  = 0.02). Instead, RF, anti-CCP, or anti-MCV were not associated with SS, chronic anemia, or peripheral neuropathy. Levels of anti-CCP correlated with the score of the Health Assessment Questionnaire-Disability Index (HAQ-Di) ( r  = 0.154,  P  = 0.03), erythrocyte sedimentation rate (ESR); ( r  = 0.155,  P  = 0.03), and RF ( P  = 0.254,  P  < 0.001), whereas anti-MCV titres only correlated with RF ( r  = 0.169,  P  = 0.02). On adjusted analysis, ExRA was associated with longer age ( P  = 0.015), longer disease duration ( P  = 0.007), higher DAS-28 score ( P  = 0.002), and higher HAQ-DI score ( P  = 0.007), but serum levels of anti-CCP and anti-MCV were not associated. These findings show the need to strengthen the evaluation of the pathogenic mechanisms implied in each specific ExRA manifestation.

journal of immunology research

Anti-Cyclic Citrullinated Peptide (Anti-CCP) and Anti-Mutated Citrullinated Vimentin (Anti-MCV) Relation with Extra-Articular Manifestations in Rheumatoid Arthritis