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. Since its first publication in the medical literature, an extremely large number of references have demonstrated that the tonometric measurement of tissue perfusion is a reliable indicator of the actual condition of critically ill patients. Later a new method was developed by the introduction of sublingual tonometry for the determination of tissue perfusion. In comparison with gastric tonometry, the new method was simpler and could even be used in awake patients. Unfortunately, at present, because of severe failures of manufacturing, the device is withdrawn from commerce.  Materials and Methods . In this study, we present a new method using a newly developed tool for the P sl CO 2  measurement in sublingual tonometry as well as the data for its validation  in vitro  and  in vivo  and the results of 25 volunteers and 54 COPD patients belonging to different GOLD groups at their hospitalization due to the acute exacerbation of the disease but already in a stable condition at the time of the examination.  Results and Conclusion . The results of the performed examinations showed that the method is suitable for monitoring the actual condition of the patients by mucosal perfusion tonometry in the sublingual region.

critical care research and practice

A Newly Developed Sublingual Tonometric Method for the Evaluation of Tissue Perfusion and Its Validation<i>In Vitro</i>and in Healthy Persons<i>In Vivo</i>and the Results of the Measurements in COPD Patients

A Newly Developed Sublingual Tonometric Method for the Evaluation of Tissue Perfusion and Its ValidationIn Vitroand in Healthy PersonsIn Vivoand the Results of the Measurements in COPD Patients