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Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. C57BL/6 mice received 10 5  red blood cells infected with  Plasmodium berghei  ANKA intraperitoneally. Noninfected mice were used as controls. Capsazepine or vehicle was given intraperitoneally for 6 days. Mice were culled on day 7 after infection and blood and spleen cell phenotype and activation were evaluated. Capsazepine decreased circulating but not spleen F4/80 + Ly6G +  cell numbers as well as activation of both F4/80 + and F4/80 + Ly6G +  cells in infected animals. In addition, capsazepine increased circulating but not spleen GR1 +  and natural killer (NK) population, without interfering with natural killer T (NKT) cell numbers and blood NK and NKT activation. However, capsazepine diminished CD69 expression in spleen NKT but not NK cells. Infection increased lipid peroxidation and the release of TNF α  and IFN γ , although capsazepine-treated group exhibited lower levels of lipid peroxidation and TNF α . Capsazepine treatment did not affect parasitaemia. Overall, TRPV1 antagonism modulates the innate immune response to malaria.

TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected withPlasmodium bergheiANKA