English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Adipose tissue receptors  C5aR  and  C5L2  and their heterodimerization/functionality and interaction with ligands  C5a  and acylation stimulating protein (ASP) have been evaluated in cell and rodent studies. Their contribution to obesity factors in humans remains unclear. We hypothesized that  C5a  receptors, classically required for host defense, are also associated with adiposity. Anthropometry and fasting blood parameters were measured in 136 women divided by body mass index (BMI): normal/overweight (≤30 kg/m 2 ;  n  = 34), obese I (≤45 kg/m 2 ;  n  = 33), obese II (≤51 kg/m 2 ;  n  = 33), and obese III (≤80 kg/m 2 ;  n  = 36). Subcutaneous and omental adipose tissue  C5aR  and  C5L2  expression were analysed.  C5L2  expression was comparable between subcutaneous and omental across all BMI groups. Plasma ASP and ASP/omental  C5L2  expression increased with BMI ( P  < 0.001 and  P  < 0.01, resp.). While plasma  C5a  was unchanged,  C5aR  expression decreased with increasing BMI in subcutaneous and omental tissues ( P  < 0.01 and  P  < 0.05, resp.), with subcutaneous omental depots. Omental  C5L2/C5aR  ratio increased with BMI ( P  < 0.01) with correlations between  C5L2/C5aR  and waist circumference, HDL-C, and adiponectin. Tissue and BMI differences in receptors and ligands, particularly in omental, suggest relationship to metabolic disturbances and highlight adipose-immune interactions.

Association of Immune and Metabolic ReceptorsC5aRandC5L2with Adiposity in Women