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Bacteriocins, ribosomally synthesized antimicrobial peptides, display potential applications in agriculture, medicine, and industry. The present study highlights integral statistical optimization and partial characterization of a bacteriocin substance from a soil bacterium taxonomically affiliated as  Bacillus  sp. YAS 1 after biochemical and molecular identifications. A sequential statistical approach (Plackett-Burman and Box-Behnken) was employed to optimize bacteriocin (BAC YAS 1) production. Using optimal levels of three key determinants (yeast extract (0.48% (w/v), incubation time (62 hrs), and agitation speed (207 rpm)) in peptone yeast beef based production medium resulted in 1.6-fold enhancement in BAC YAS 1 level (470 AU/mL arbitrary units against  Erwinia amylovora ). BAC YAS 1 showed activity over a wide range of pH (1–13) and temperature (45–80°C). A wide spectrum antimicrobial activity of BAC YAS 1 against the human pathogens ( Clostridium perfringens ,  Staphylococcus epidermidis ,  Campylobacter jejuni ,  Enterobacter aerogenes ,  Enterococcus  sp.,  Proteus  sp.,  Klebsiella  sp., and  Salmonella typhimurium ), the plant pathogen ( E. amylovora ), and the food spoiler ( Listeria innocua ) was demonstrated. On top and above, BAC YAS 1 showed no antimicrobial activity towards lactic acid bacteria ( Lactobacillus bulgaricus ,  L. casei ,  L. lactis , and  L. reuteri ). Promising characteristics of BAC YAS 1 prompt its commercialization for efficient utilization in several industries.

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A Sequential Statistical Approach towards an Optimized Production of a Broad Spectrum Bacteriocin Substance from a Soil Bacterium<i>Bacillus</i>sp. YAS 1 Strain

A Sequential Statistical Approach towards an Optimized Production of a Broad Spectrum Bacteriocin Substance from a Soil BacteriumBacillussp. YAS 1 Strain