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Green tea and hibiscus are widely consumed as traditional beverages in Yemen and some regional countries. They are relatively cheap and the belief is that they improve health state and cure many diseases. The aim of this study was to evaluate the potential protective and antibacterial activity of these two famous plants  in vitro  through measuring their antibacterial activity and  in vivo  through measuring nonenzymatic kidney markers dysfunction after induction of nephrotoxicity by gentamicin. Gram positive bacteria like MRSA (methicillin resistant  Staphylococcus aureus ) were isolated from hospitalized patients' different sources (pus and wound) and Gram negative bacteria including  E. coli  and  P. aeruginosa  were used  in vitro  study. In addition, the efficacy of these plants was assessed  in vivo  through measuring nonenzymatic kidney markers including S. creatinine and S. urea. Green tea was shown antimicrobial activity against MRSA with inhibition zone 19.67 ± 0.33 mm and MIC 1.25 ± 0.00 mg/mL compared with standard reference (vancomycin) 18.00 ± 0.00 mg/mL. Hibiscus did not exhibit a similar effect. Both Hibiscus- and green tea-treated groups had nephroprotective effects as they reduced the elevation in nonenzymatic kidney markers. We conclude that green tea has dual effects: antimicrobial and nephroprotective.

advances in pharmacological sciences

Evaluation of the Potential Nephroprotective and Antimicrobial Effect ofCamellia sinensisLeaves versusHibiscus sabdariffa(In VivoandIn VitroStudies)