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Salmonella enterica  serovar Typhi ( S . Typhi) is a human-specific pathogen that causes typhoid fever. In this study, we constructed Δ ygaE  mutant and a microarray was performed to investigate the role of  ygaE  in regulation of gene expression changes in response to hyperosmotic stress in  S . Typhi. qRT-PCR was performed to validate the microarray results. Our data indicated that  ygaE  was the repressor of  gab  operon in  S . Typhi as in  Escherichia coli  ( E. coli ), though the sequence of  ygaE  is totally different from  gabC  (formerly  ygaE ) in  E. coli . OmpF, OmpC, and OmpA are the most abundant out membrane proteins in  S . Typhi. Here we report that YgaE is a repressor of both OmpF and OmpC at the early stage of hyperosmotic stress. Two-dimensional electrophoresis was applied to analyze proteomics of total proteins in wild-type strain and Δ ygaE  strain and we found that YgaE represses the expression of OmpA at the late stage of hyperosmotic stress. Altogether, our results implied that YgaE regulates out membrane proteins in a time-dependent manner under hyperosmotic stress in  S . Typhi.

YgaE Regulates Out Membrane Proteins inSalmonella entericaSerovar Typhi under Hyperosmotic Stress