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This study aims to investigate the anti-inflammatory responses and mechanisms of  Siegesbeckia orientalis  ethanol extract (SOE). In cell culture experiments, RAW264.7 cells were pretreated with SOE and stimulated with lipopolysaccharide (LPS) for inflammatory mediators assay. In animal experiments, mice were tube-fed with SOE for 1 week, and s.c. injected with  λ -carrageenan or i.p. injected with LPS to simulate inflammation. The degree of paw edema was assessed, and cytokine profile in sera and mouse survival were recorded. Data showed that SOE significantly reduced NO, IL-6, and TNF-α production in LPS-stimulated RAW264.7 cells.  In vivo  studies demonstrated that mice supplemented with 32 mg SOE/kg BW/day significantly lowered sera IL-6 level and resulted a higher survival rate compared to the control group ( P  = 0.019). Furthermore, SOE inhibited LPS-induced NF- κ B activation by blocking the degradation of I κ B-α. The SOE also reduced significantly the phosphorylation of ERK1/2, p38, and JNK in a dose-dependent manner. In summary, the  in vitro  and  in vivo  evidence indicate that SOE can attenuate acute inflammation by inhibiting inflammatory mediators via suppression of MAPKs- and NF- κ B-dependent pathways.

Anti-Inflammatory Effects ofSiegesbeckia orientalisEthanol Extract inIn VitroandIn VivoModels