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The anti- Candida  activity of essential oil from  Cinnamomum zeylanicum  Blume, as well as its effect on the roughness and hardness of the acrylic resin used in dental prostheses, was assessed. The safety and tolerability of the test product were assessed through a phase I clinical trial involving users of removable dentures. Minimum inhibitory concentration (MIC) and minimum fungicidal concentrations (MFC) were determined against twelve  Candida  strains. Acrylic resin specimens were exposed to artificial saliva (GI),  C. zeylanicum  (GII), and nystatin (GIII) for 15 days. Data were submitted to ANOVA and Tukey posttest ( α  = 5%). For the phase I clinical trial, 15 healthy patients used solution of  C. zeylanicum  at MIC (15 days, 3 times a day) and were submitted to clinical and mycological examinations.  C. zeylanicum  showed anti- Candida  activity, with MIC = 625.0  µ g/mL being equivalent to MFC. Nystatin caused greater increase in roughness and decreased the hardness of the material ( P  < 0.0001), with no significant differences between GI and GII. As regards the clinical trial, no adverse clinical signs were observed after intervention. The substance tested had a satisfactory level of safety and tolerability, supporting new advances involving the clinical use of essential oil from  C. zeylanicum.

evidence-based complementary and alternative medicine

Safety and Tolerability of Essential Oil from<i>Cinnamomum zeylanicum</i>Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin

Safety and Tolerability of Essential Oil fromCinnamomum zeylanicumBlume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin