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The study aimed at testing the hypothesis that tongxinluo capsule might exert its cardioprotective effect by preventing ventricular remodeling and improving coronary microvascular function in a rat model of doxorubicin-induced dilated cardiomyopathy (DCM). Rats that survived DCM induction were randomly divided into three groups to be given 1.5 g·kg−1·day−1 (TXL-H, n = 9 ) or 0.15 g·kg−1·day−1 (TXL-L, n = 10 ) of tongxinluo, or normal saline at the same volume (DCM-C, n = 10 ) intragastrically. Age matched normal rats treated with normal saline were used as normal controls (NOR-C, n = 9 ). After four weeks of treatment, the DCM-C, TXL-H, and TXL-L groups exhibited significant cardiac dysfunction, left ventricular remodeling, and coronary microvascular dysfunction, compared with the NOR-C rats. However, myocardial functional parameters were significantly improved and microvascular density (MVD) increased in the TXL-H group compared with the DCM-C group (all P < 0.01 ). Left ventricular remodeling was prevented. There were close linear relationships between CVF and LVEF ( r = - 0.683 , P < 0.05 ), MVD and LVEF ( r = 0.895 , P < 0.05 ), and MVD and CVF ( r = - 0.798 , P < 0.05 ). It was indicated that high-dose tongxinluo effectively improved cardiac function in rat model of DCM.

Traditional Chinese Medicine Tongxinluo Improves Cardiac Function of Rats with Dilated Cardiomyopathy