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Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C,  n  = 25), vitamin sufficient, diabetes (DS-DM,  n  = 18), vitamin deficient, no diabetes (DD-C,  n  = 63), and vitamin deficient, diabetes (DD-DM,  n  = 40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups ( P  = 0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m)  versus  DD-DM (309 ± 116 m);  P  = 0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM ( P  = 0.074) even after being adjusted to physical activity ( P  = 0.069). Vitamin D deficiency can influence physical function in HF diabetic patients.

Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes