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The increasing number of multidrug-resistant microbes now emerging necessitates the identification of novel antimicrobial agents. Plants produce a great variety of antimicrobial peptides including hundreds of small, nodule-specific cysteine-rich NCR peptides that, in the legume  Medicago truncatula , govern the differentiation of endosymbiotic nitrogen fixing bacteria and,  in vitro , can display potent antibacterial activities. In this study, the potential candidacidal activity of 19 NCR peptides was investigated. Cationic NCR peptides having an isoelectric point above 9 were efficient in killing  Candida albicans , one of the most common fungal pathogens of humans. None of the tested NCR peptides were toxic for immortalized human epithelial cells at concentrations that effectively killed the fungus; however, at higher concentrations, some of them inhibited the division of the cells. Furthermore, the cationic peptides successfully inhibited  C. albicans  induced human epithelial cell death in an  in vitro  coculture model. These results highlight the therapeutic potential of cationic NCR peptides in the treatment of candidiasis.

biomed research international

Symbiotic Plant Peptides Eliminate<i>Candida albicans</i>Both<i>In Vitro</i>and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells

Symbiotic Plant Peptides EliminateCandida albicansBothIn Vitroand in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells