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Ethnopharmacological Relevance . TZQ-F has been traditionally used in Traditional Chinese Medicine as a formula for the treatment of diabetes.   Aim of the Study . This study aims to compare the pharmacologic effects and gastrointestinal adverse events between TZQ-F and acarbose.   Methods . The double-blind randomized placebo-controlled fivefold crossover study was performed in 20 healthy male volunteers. Plasma glucose, plasma IRI, and plasma C-peptide were measured to assess the pharmacologic effects. Flatus and bowel activity were measured to assess the adverse event of gastrointestinal effect.   Results . 3 and 4 tablets of TZQ decreased the  C   max  of plasma glucose compared with that of the previous day and with placebo. 3 tablets also decreased  C   max  of plasma C-peptide compared with placebo. 4 tablets increased  C   max  of plasma insulin after breakfast and the AUC of plasma C-peptide after breakfast and dinner. 2 tablets did not decrease plasma glucose and elevated the  C   max  and AUC of C-peptide after breakfast and dinner, respectively. Acarbose 50 mg decreased the  C   max  of plasma insulin and C-peptide after breakfast and the  C   max  of plasma glucose and C-peptide after dinner. The subjects who received TZQ did not report any abdominal adverse events.   Conclusions . 3 tablets of TZQ have the same effects as the acarbose.

Comparison of the Effects of Acarbose and TZQ-F, a New Kind of Traditional Chinese Medicine to Treat Diabetes, Chinese Healthy Volunteers