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Sensitization to specific olive pollen-allergens (Ole e 2 and 10) has been correlated with a clinical pattern of asthma. This study analyzes the association between several polymorphims of  TNFA  ( G-308A ,  C-857T , and  C-1031T ),  IL10  ( C-571A  and  A-1117G ), and  TGFB  ( C-509-T ) and these sensitizations. These polymorphisms were genotyped by allelic discrimination, in olive pollen-allergic patients (phenotyped for specific Ole e 2 and 10 sensitizations) and healthy controls. Levels of serum-soluble cytokines were correlated with specific genotypes and clinical phenotypes. The results showed that heterozygous  TGFB C-509T  genotype, besides having the lowest sera TGF- levels, was significantly increased in olive pollen-allergic patients compared with controls. According specific sensitizations,  CC  genotype of  IL10 C - 571A  could be a protective factor for Ole e 2 sensitization and mainly for asthmatic Ole e 2 sensitized patients compared with asthmatic non-Ole e 2 sensitized patients (OR: 0.26,  P  = 0.008). In contrast, heterozygous  CA  genotype was increased in Ole e 2 asthmatic subjects compared to asthmatic non-Ole e 2 sensitized patients. Lastly, heterozygous  TNFA G-308A  genotype was associated with Ole e 10 sensitization (OR: 2.5,  P  = 0.04). In conclusion, these results suggest a role of TGF- β 1 in olive-pollen sensitization and TNF- α  and IL-10 genotypes in the asthma induced by specific olive-pollen allergens.

journal of immunology research

Polymorphisms of Tumor Necrosis Factor-<i>α</i>, Transforming Growth Factor-<i>β</i>, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization

Polymorphisms of Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization