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Gloriosa superba  and  Catharanthus roseus  are useful in traditional medicine for treatment of various skin diseases and cancer. However, their molecular effect on psoriasis has not been investigated. In this study, the effect of ethanol extracts derived from  G. superba  leaves and  C. roseus  stems on the expression of psoriatic marker, keratin 17 (K17), was investigated in human keratinocytes using biochemical and molecular experimental approaches. Both extracts could reduce the expression of K17 in a dose-dependent manner through JAK/STAT pathway as demonstrated by an observation of reduced phosphorylation of STAT3 (p-STAT3). The inhibitory activity of  G. superba  extract was more potent than that of  C. roseus . The Pearson's correlation between K17 and cell viability was shown positive. Taken together, the extracts of  G. superba  and  C. roseus  may be developed as alternative therapies for psoriasis.

Effect ofGloriosa superbaandCatharanthus roseusExtracts on IFN-γ-Induced Keratin 17 Expression in HaCaT Human Keratinocytes