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Background and Objectives . The aim of this study was to determine the frequency of  bla   NDM ,  bla   PER ,  bla   VEB ,  bla   IMP , and  bla   VIM  type genes among  A. baumannii  isolates from hospitalized patients in two hospitals in Tehran, Iran.  Patients and Methods . Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion and Broth microdilution methods. The frequency of MBL (metallo-beta-lactamase) and ESBL (extended-spectrum-beta-lactamase) producers was evaluated by CDDT. The  β   -lactamases  genes were detected by PCR and sequencing methods.  Results . The resistance of  A. baumannii  isolates against tested antibiotics was as follows: 103 (95.4%) to ceftazidime, 108 (100%) to cefotaxime, 105 (95.7%) to cefepime, 99 (91.7%) to imipenem, 99 (91.7%) to meropenem, 87 (80.6%) to amikacin, 105 (97.2%) to piperacillin, 100 (92.6%) to ciprofloxacin, 103 (95.4%) to piperacillin/tazobactam, 44 (40.7%) to gentamicin, 106 (98.1%) to ampicillin/sulbactam, 106 (98.1%) to co-trimoxazole, 87 (80.6%) to tetracycline, and 1 (1.8%) to colistin. Using combined disk diffusion test, 91 (84.2%) and 86 (86.86%) were ESBL and MBL producers, respectively. The prevalence of  bla   PER-1 ,  bla   VEB-1 ,  bla   IMP-1 , and  bla   VIM-1  genes was 71 (78.03%), 36 (39.5%), 3 (3.48%), and 15 (17.44%), respectively.  Conclusions . The prevalence of ESBLs and MBLs-producing  A. baumannii  strains detected in this study is a major concern and highlights the need of infection control measures.

scientifica

Prevalence ofblaNDM,blaPER,blaVEB,blaIMP, andblaVIMGenes amongAcinetobacter baumanniiIsolated from Two Hospitals of Tehran, Iran