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Desmostachya bipinnata  Stapf (Poaceae/Gramineae) is an official drug of ayurvedic pharmacopoeia. Various parts of this plant were used extensively in traditional and folklore medicine to cure various human ailments. The present study was aimed to evaluate the antioxidant and DNA damage protection activity of hydroalcoholic extract of  Desmostachya bipinnata  both  in vitro  and  in vivo , to provide scientific basis for traditional usage of this plant. The extract showed significant antioxidant activity in a dose-dependent manner with an IC 50  value of 264.18 ± 3.47   μ  g/mL in H 2 O 2  scavenging assay and prevented the oxidative damage to DNA in presence of DNA damaging agent (Fenton's reagent) at a concentration of 50   μ  g/mL. Also, the presence of extract protected yeast cells in a dose-dependent manner against DNA damaging agent (Hydroxyurea) in spot assay. Moreover, the presence of extract exhibited significant antioxidant activity  in vivo  by protecting yeast cells against oxidative stressing agent (H 2 O 2 ). Altogether, the results of current study revealed that  Desmostachya bipinnata  is a potential source of antioxidants and lends pharmacological credence to the ethnomedical use of this plant in traditional system of medicine, justifying its therapeutic application for free-radical-induced diseases.

Evaluation of Antioxidant and DNA Damage Protection Activity of the Hydroalcoholic Extract ofDesmostachya bipinnataL. Stapf