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Background . Magnolin is the major active ingredient of the herb  Magnolia fargesii  which has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties.  Methods . To test whether Magnolin could attenuate CIN, oxidative stress and apoptosis,  in vivo  and  in vitro , we utilized a rat model of ioversol-induced CIN and a cell model of oxidative stress in which HK2 cells were treated with H 2 O 2 . Rats were assigned to 4 groups ( n  = 6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (CIN rats pretreated with vehicle), and Magnolin group (CIN rats pretreated with 1 mg/kg Magnolin).  Results . The results showed that magnolin ameliorated the renal tubular necrosis, apoptosis, and the deterioration of renal function ( P  < 0.05). Furthermore, Magnolin reduced the renal oxidative stress, suppressed caspase-3 activity, and increased Bcl-2 expression  in vivo  and  in vitro .  Conclusion . Magnolin might protect CIN in rats through antioxidation and antiapoptosis.

Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis