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The purpose of this study was to investigate the effect of fermented mushroom of   Cordyceps sinensis  (CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals showed 40% tumor incidence ( P  < 0.05). Se-CS also enhanced the immune functions. Se-CS treatment showed significant ( P  < 0.05–0.01) restoration in the level of glutathione content, lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na + /K + -ATPase activity, and glutathione S transferase activity. This finding suggested that the concomitant use of Se and CS could be a potential therapeutic approach to improve the efficacy of therapy for uterine cervical cancer.

Effects of Fermented Mushroom ofCordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer