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Pharmacokinetic characters of rhynchophylline (RIN), gastrodin (GAS), and gastrodigenin ( p -hydroxybenzyl alcohol, HBA) were investigated after oral administration of different prescriptions of  Yizhi :  Yizhi  tablets or effective parts of  tianma  (total saponins from Gastrodiae, EPT) and  gouteng  (rhynchophylla alkaloids, EPG). At different predetermined time points after administration, the concentrations of GAS, HBA, and RIN in rat plasma were determined by an HPLC-ESI/MS method, and the main pharmacokinetic parameters were investigated. The results showed that the pharmacokinetic parameters  C   max  and AUC 0– ∞   ( P  < 0.05) were dramatically different after oral administration of different prescriptions of  Yizhi . The data indicated that the pharmacokinetic processes of GAS, HBA, and RIN in rats would interact with each other or be affected by other components in  Yizhi . The rationality of the compatibility of  Uncaria  and  Gastrodia elata  as a classic “herb pair” has been verified from the pharmacokinetic viewpoint.

evidence-based complementary and alternative medicine

Pharmacokinetic Comparative Study of Gastrodin and Rhynchophylline after Oral Administration of Different Prescriptions of<i>Yizhi</i>Tablets in Rats by an HPLC-ESI/MS Method

Pharmacokinetic Comparative Study of Gastrodin and Rhynchophylline after Oral Administration of Different Prescriptions ofYizhiTablets in Rats by an HPLC-ESI/MS Method