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Type 2 diabetes mellitus is one of the most frequent causes of death in Mexico, characterized by chronic hyperglycemia. One alternative strategy for this metabolic abnormality is inhibiting the enzymes responsible for the metabolism of carbohydrates. We evaluated whether the aqueous  Citrus limetta  peel extract could inhibit the metabolism of carbohydrates. We found that this extract inhibited primarily the enzyme  α -amylase by 49.6% at a concentration of 20 mg/mL and to a lesser extent the enzyme  α -glucosidase with an inhibition of 28.2% at the same concentration. This inhibition is likely due to the high polyphenol content in the  Citrus limetta  peel (19.1 mg GAE/g). Antioxidant activity of the  Citrus limetta  peel demonstrated dose-dependent antioxidant activity, varying from 6.5% at 1.125 mg/mL to 42.5% at 20 mg/mL. The study of these polyphenolic compounds having both antihyperglycemic and antioxidant activities may provide a new approach to the management of type 2 diabetes mellitus.

the scientific world journal/thescientificworldjournal

Evaluation of the Inhibition of Carbohydrate Hydrolyzing Enzymes, the Antioxidant Activity, and the Polyphenolic Content of<i>Citrus limetta</i>Peel Extract

Evaluation of the Inhibition of Carbohydrate Hydrolyzing Enzymes, the Antioxidant Activity, and the Polyphenolic Content ofCitrus limettaPeel Extract