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The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of high grade B-cell lymphoma, intermediate between DLBCL and BL, lacking CD10 expression in which the chromosomal translocation t(3;8)(q27;q24) was found to be the sole chromosomal abnormality. FISH analysis demonstrated juxtaposition of the  BCL6  and  MYC  loci without obvious involvement of the  IGH  locus, suggesting constitutive  MYC  expression due to promoter substitution. The patient responded to intensive chemotherapy and remains in remission two years after finishing therapy.

A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of theBCL6andMYCLoci Associated with Good Clinical Outcome