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There has recently been increased interest in the potential health effects of omega-3 polyunsaturated fatty acids on the immune system. Paracoccidioidomycosis is the most important endemic mycosis in Latin America. Macrophages have a fundamental role and act as first line of organism defense. The purpose of this study was to analyze the effect of n-3 fatty acids on the production of PGE 2  and NO by mice infected with Pb18 and fed a diet enriched with LNA for 8 weeks. To study the effect of omega-3 fatty acids on macrophage activity during experimental paracoccidioidomycosis, mice were infected with Pb18 and fed a diet supplemented with LNA. PGE 2  in the serum of animals was analyzed and NO in the supernatants of macrophages cultured and challenged  in vitro  with Pb18 was measured. Omega-3 fatty acids seemed to decrease the production of PGE 2    in vivo  in the infected group fed an LNA-supplemented diet during the 4th and 8th weeks of the experiment. At the same time, we observed an increase in synthesis of NO by peritoneal macrophages in this group. Omega-3 fatty acids thus appear to have an immunomodulatory effect in paracoccidioidomycosis.

biomed research international

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E<sub>2</sub>and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E2and Nitric Oxide during Experimental Murine Paracoccidioidomycosis

Role of Omega-3 Polyunsaturated Fatty Acids in the Production of Prostaglandin E₂and Nitric Oxide during Experimental Murine Paracoccidioidomycosis