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Breast cancer (BC) is the most common cancer of women all over the world.  BRCA1  and  BRCA2  gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of  BRCA1  and  BRCA2  mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important  BRCA1  and  BRCA2  alterations which have been encountered in most of the populations. After those Ashkenazi founder mutations, 300T>G also demonstrated sparse frequency in African American and European populations. This review affords quick access to the most frequent alterations among various populations which could be helpful in BRCA screening programs.

A Comprehensive Focus on Global Spectrum ofBRCA1andBRCA2Mutations in Breast Cancer