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Helicobacter pylori  colonization of gastric mucosa causes pain of unknown etiology in about 15–20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic  H. pylori  infected patients. To diagnose  H. pylori  infection, histological analysis and the urea breath test (UBT C13) were performed. The levels of mRNA expression of arylalkylamine-N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT) were estimated in gastric mucosa with RT-PCR. The level of AA-NAT expression and AMST was decreased in  H. pylori  infected patients and was increased after  H. pylori  eradication. We conclude that decreased expression of melatonin synthesizing enzymes, AA-NAT and ASMT, in patients with symptomatic  H. pylori  infection returns to normal level after  H. pylori  eradication.

Expression of Melatonin Synthesizing Enzymes inHelicobacter pyloriInfected Gastric Mucosa