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The dog is considered the main domestic reservoir for  Trypanosoma cruzi  infection and a suitable experimental animal model to study the pathological changes during the course of Chagas disease (CD). Vaccine development is one of CD prevention methods to protect people at risk. Two plasmids containing genes encoding a  trans -sialidase protein (TcSP) and an amastigote-specific glycoprotein ( TcSSP4 ) were used as DNA vaccines in a canine model. Splenomegaly was not found in either of the recombinant plasmid-immunized groups; however, cardiomegaly was absent in animals immunized only with the plasmid containing the  TcSSP4  gene. The inflammation of subendocardial and myocardial tissues was prevented only with the immunization with  TcSSP4  gene. In conclusion, the vaccination with these genes has a partial protective effect on the enlargement of splenic and cardiac tissues during the chronic CD and on microscopic hearth damage, since both plasmids prevented splenomegaly but only one avoided cardiomegaly, and the lesions in heart tissue of dog immunized with plasmid containing the  TcSSP4  gene covered only subepicardial tissue.

biomed research international

Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic<i>Trypanosoma cruzi</i>Infection in the Canine Model

Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental ChronicTrypanosoma cruziInfection in the Canine Model