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Polyamines are substances involved in many aspects of cell growth, division, and differentiation. Because of the metabolic differences between host cells and parasite cells, polyamine metabolism has been considered as a potential target for the chemotherapy of parasitic diseases. The aim of this work was to evaluate the schistosomicidal activity of different  N -alkylated diamines ( 3a – 3h ), amino alcohols ( 4a – 4d ), and glycosylated amino alcohols ( 10a – 10d ). Compounds were prepared by synthetic methods and submitted to  in vitro  evaluation against adult worms of  Schistosoma mansoni . At 100  μ M,  3b ,  3e , and  3h  as well as  4a ,  4b ,  4d ,  10a ,  10b , and  10d  resulted in 100% mortality of adult schistosomes. Compound  3d  (12.5 to 100  μ M) caused the death of 100% of both male and female adult schistosomes, while  3f  (12.5 to 100  μ M) resulted in 100% mortality of only male adult worms, whereas no mortality in female worms was observed. Compounds  3d  and  3f  were also able to reduce viability and decrease production of developed eggs in comparison with the negative control group. Diamines  3d  and  3f  may represent useful lead compounds for further optimization in order to develop new schistosomicidal agents.

Anthelmintic Effects of Alkylated Diamines and Amino Alcohols againstSchistosoma mansoni