English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides  8(a–e) /carbothioamides  8(f–j)  were accomplished for biological interest by the simple addition of active functionalized arylisocyanates  7(a–e) /arylisothiocyanates  7(f–j)  with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile  (4) . Compound  4  was synthesized in high yields (94%) by the condensation reaction of febuxostat (1) with piperazine using a selective reagent such as propylphosphonic anhydride (T 3 P). Antiviral activity against  Tobacco mosaic virus  (TMV) and antimicrobial activity of the synthesized compounds were evaluated. Biological data revealed that 4-nitrophenyl substituted urea  8d , and 3-bromophenyl substituted thiourea  8f  exhibited promising antiviral activities. Moreover, 4-fluorophenyl substituted urea  8a , 4-nitrophenyl substituted urea  8d , 3-bromophenyl substituted thiourea  8f , and 2,4-dichlorophenyl substituted thiourea  8j  exhibited potent antimicrobial activity.

New Urea and Thiourea Derivatives of Piperazine Doped with Febuxostat: Synthesis and Evaluation of Anti-TMV and Antimicrobial Activities