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The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca 2+  overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca 2+  channel (VDC) and Na + /Ca 2+  exchanger (NCX) system are the main pathways of intracellular Ca 2+  overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca 2+  overload in the contrast media-induced renal tubular cell injury and renal hemodynamic disorder.

biomed research international

Role of Intracellular Ca2+and Na+/Ca2+Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury