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Purpose . To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP).  Methods . Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4).  Results . The mean MD slopes were −0.55/−0.39 (right/left eyes,  n  = 19) dB/year in the treated group and −1.37/−1.15 (right/left eyes,  n  = 22) dB/year in the control group ( P  = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values.  Conclusion . Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.

Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study