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Systemic mycotic infections have been increasing in incidence in immunocompromised patients. Although yeasts are most often isolated, opportunistic fungal infections may also be caused by filamentous fungi, including  Aspergillus  and  Fusarium . Like  Aspergillus ,  Fusarium  is angioinvasive with an ability to disseminate widely. Disseminated fusariosis is most commonly linked to prolonged neutropenia. Disseminated infections due to  Fusarium  are rare in Human Immunodeficiency Virus (HIV) positive patients but have been reported in HIV positive patients with neutropenia and lymphoma. We describe an HIV positive patient without neutropenia, skin lesions, or concomitant malignancy, who developed fatal disseminated infection with possible endocarditis due to  Fusarium solani . Early identification of  Fusarium  is important because of its high level of resistance to several antifungal drugs, with response often requiring combination therapy.

Fatal DisseminatedFusariumInfection in a Human Immunodeficiency Virus Positive Patient