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Human cytomegalovirus (HCMV) infection causes significant morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this work, we characterized the phenotype and interferon-gamma (INF- γ ) production of HCMV-specific T cells using QuantiFERON-HCMV assay in 26 patients 6 months after HSCT. We analysed whether these two parameters were associated with clinical variables. Our results showed that the patients receiving stem cells from donors ≥40 years old were 12 times more likely to have HCMV-specific CD8+ T cells with “differentiated phenotype” (CD45RA+CCR7+ ≤6.7% and CD28+ ≤30%) than patients grafted from donors <40 years old (OR = 12;  P  = 0.014). In addition, a detectable IFN- γ  production in response to HCMV peptides (cutoff 0.2 IU/mL IFN- γ ; “reactive” QuantiFERON-HCMV test) was statistically associated with HCMV replication after transplantation (OR = 11;  P  = 0.026), recipients ≥40 versus <40 years old (OR = 11;  P  = 0.026), and the use of peripheral blood versus bone marrow as stem cell source (OR = 17.5;  P  = 0.024). In conclusion, donor age is the only factor significantly associated with the presence of the “differentiated phenotype” in HCMV-specific CD8+ T cells, whereas HCMV replication after transplantation, recipient age, and stem cell source are the factors associated with the production of IFN- γ  in response to HCMV epitopes.

clinical and developmental immunology/clinical and developmental immunology

Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation