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Considering the adverse effects of DL-homocysteine thiolactone hydrochloride (DL-Hcy TLHC) on vascular function and the possible role of oxidative stress in these mechanisms, the aim of this study was to assess the influence of DL-Hcy TLHC alone and in combination with specific inhibitors of important gasotransmitters, such as L-NAME, DL-PAG, and PPR IX, on cardiac contractility, coronary flow, and oxidative stress markers in an isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique at a 70 cm H 2 O and administered 10   μ  M DL-Hcy TLHC alone or in combination with 30   μ  M L-NAME, 10   μ  M DL-PAG, or 10   μ  M PPR IX. The following parameters were measured:  dp/dt  max,  dp/dt  min, SLVP, DLVP, MBP, HR, and CF. Oxidative stress markers were measured spectrophotometrically in coronary effluent through TBARS, NO 2 , O 2   − , and H 2 O 2  concentrations. The administration of DL-Hcy TLHC alone decreased  dp/dt  max, SLVP, and CF but did not change any oxidative stress parameters. DL-Hcy TLHC with L-NAME decreased CF, O 2   − , H 2 O 2 , and TBARS. The administration of DL-Hcy TLHC with DL-PAG significantly increased  dp/dt  max but decreased DLVP, CF, and TBARS. Administration of DL-Hcy TLHC with PPR IX caused a decrease in  dp/dt  max, SLVP, HR, CF, and TBARS.

biomed research international

Effects of DL-Homocysteine Thiolactone on Cardiac Contractility, Coronary Flow, and Oxidative Stress Markers in the Isolated Rat Heart: The Role of Different Gasotransmitters