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Periodic monitoring of  Staphylococcus aureus  characteristics in a locality is imperative as their drug-resistant variants cause treatment problem. In this study, antibiograms, prevalence of toxin genes ( sea-see, seg-ser, seu, tsst-1, eta, etb , and  etd ), PFGE types, accessory gene regulator ( agr ) groups, and ability to form biofilm of 92  S. aureus  Thailand clinical isolates were investigated. They were classified into 10 drug groups: groups 1–7 (56 isolates) were methicillin resistant (MRSA) and 8–10 (36 isolates) were methicillin sensitive (MSSA). One isolate did not have any toxin gene, 4 isolates carried one toxin gene ( seq ), and 87 isolates had two or more toxin genes. No isolate had  see, etb , or  tsst-1 ; six isolates had  eta  or  etd . Combined  seg-sei-sem-sen-seo  of the highly prevalent  egc  locus was 26.1%. The  seb, sec, sel, seu , and  eta  associated significantly with MSSA;  sek  was more in MRSA. The  sek-seq  association was 52.17% while combined  sed-sej  was not found. Twenty-three PFGE types were revealed, no association of toxin genes with PFGE types. All four  agr  groups were present;  agr  group 1 was predominant (58.70%) but  agr  group 2 strains carried more toxin genes and were more frequent toxin producers. Biofilm formation was found in 72.83% of the isolates but there was no association with antibiograms. This study provides insight information on molecular and phenotypic markers of Thailand  S. aureus  clinical isolates which should be useful for future active surveillance that aimed to control a spread of existing antimicrobial resistant bacteria and early recognition of a newly emerged variant.

Staphylococcus aureusClinical Isolates: Antibiotic Susceptibility, Molecular Characteristics, and Ability to Form Biofilm