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Background . Present study was designed to report the effect of 2% creatine monohydrate supplementation for 8, 12 and 15 weeks on hematology and serum biochemical profile of male albino mouse following hypoxic ischemic insult on postnatal day 10.  Methods . 66 Blood samples (2% creatine monohydrate supplemented ( N  = 34) and unsupplemented ( N  = 32)) were analyzed for various hematological (blood glucose, packed cell volume, total WBC count, total RBC count) and serum biochemical parameters (cholesterol, AST, ALT, HDL, LDL, total protein, triglycerides).  Results . ALT had higher concentrations in mice feeding on normal diet for 8 ( P  > 0.01) and 12 weeks ( P  > 0.01) following asphyxia and in 12 weeks treatment without asphyxia ( P  = 0.006) when compared with the creatine supplemented mice. LDL ( P  = 0.011) and cholesterol ( P  > 0.01) had higher concentrations in mice on normal diet for 12 weeks following hypoxia ischemia. Cholesterol ( P  > 0.01) in 12 and glucose ( P  = 0.006) in 15 week treatment group had significantly lower concentrations in creatine supplemented male albino mice when compared with untreated group following hxpoic-ischemic insult.  Conclusion . We concluded that creatine supplementation following hypoxic ischemic insult helps in maintain the normal blood chemistry.

the scientific world journal/thescientificworldjournal

Effect of Creatine Monohydrate Supplementation on Various Hematological and Serum Biochemical Parameters of Male Albino Mice following Neonatal Hypoxia-Ischemia Encephalopathy