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Hypertension is one of the very serious diseases and, recently, hypertensive patient longevity has been increased significantly. Therefore, the development of new antihypertensive drugs or bioactive compounds is very important to remedy or prevent hypertension. The antihypertensive angiotensin I-converting enzyme (ACE) inhibitor in water extracts from the brown-cultivar-fruiting-body of  Hypsizygus marmoreus  was purified with ultrafiltration, C 18  solid phase extraction chromatography and reverse-phase HPLC, and the purified ACE inhibitor with inhibitory activity of IC 50  value of 0.19 mg/mL was obtained. The purified ACE inhibitor was found to be a new oligopeptide with the sequence LSMGSASLSP. Its molecular weight was estimated to be 567.3 Da and the water extracts containing ACE inhibitor from  Hypsizygus marmoreus  showed a clear antihypertensive action a spontaneously hypertensive rat.

Characterization of an Antihypertensive Angiotensin I-Converting Enzyme Inhibitory Peptide from the Edible MushroomHypsizygus marmoreus